Ontology highlight
ABSTRACT:
SUBMITTER: McMahon KM
PROVIDER: S-EPMC5355259 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
McMahon Kaylin M KM Scielzo Cristina C Angeloni Nicholas L NL Deiss-Yehiely Elad E Scarfo Lydia L Ranghetti Pamela P Ma Shuo S Kaplan Jason J Barbaglio Federica F Gordon Leo I LI Giles Francis J FJ Thaxton C Shad CS Ghia Paolo P
Oncotarget 20170201 7
Chronic lymphocytic leukemia (CLL) remains incurable despite the introduction of new drugs. Therapies targeting receptors and pathways active specifically in malignant B cells might provide better treatment options. For instance, in B cell lymphoma, our group has previously shown that scavenger receptor type B-1 (SR-B1), the high-affinity receptor for cholesterol-rich high-density lipoproteins (HDL), is a therapeutic target. As evidence suggests that targeting cholesterol metabolism in CLL cells ...[more]