Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis.
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ABSTRACT:
SUBMITTER: Sun J
PROVIDER: S-EPMC5355280 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis.
Sun Jian J Liu Xuan X Gao Hong H Zhang Long L Ji Qing Q Wang Ziyuan Z Zhou Lihong L Wang Yan Y Sui Hua H Fan Zhongze Z Li Qi Q
Oncotarget 20170201 7
Bone morphogenetic proteins (BMPs) both promote and suppress tumorigenesis, and multiple BMP antagonists reportedly contribute to cancer progression. In this study, we demonstrated that the BMP antagonist Chordin-like 2 (CHRDL2) is upregulated in colorectal cancer (CRC) tissues, and that CHRDL2 levels correlate with clinical features of CRC patients, including tumor size, TNM staging, and tumor differentiation. In addition, survival rate and Cox proportional hazards model analyses showed that hi ...[more]
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