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Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal.


ABSTRACT: The aim of this study was to investigate the protective effects of matrine on lipopolysaccharide (LPS)-induced inflammation and oxidative stress in vivo and in vitro. The results showed that matrine improved intestinal inflammatory status and oxidative balance and enhanced chemokine receptor 7 (CCR7) expression. In LPS-challenged mice and Caco-2 cells, matrine alleviated LPS-induced inflammation and oxidative stress via downregulating pro-inflammatory cytokines (IL-1? and IL-17) and malondialdehyde (MDA) production. CCR7-siRNA transfection blocked the protective effects of matrine on LPS-induced inflammation and oxidative stress and exacerbated LPS caused injury. In conclusion, matrine alleviates LPS-induced intestinal inflammation and oxidative stress in mice and Caco-2 cells, which may be associated with CCR7 signal.

SUBMITTER: Wu G 

PROVIDER: S-EPMC5355291 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal.

Wu Guojun G   Zhou Wenhong W   Zhao Junfeng J   Pan Xiaohua X   Sun Yongjie Y   Xu Hao H   Shi Peng P   Geng Chong C   Gao Ling L   Tian Xingsong X  

Oncotarget 20170201 7


The aim of this study was to investigate the protective effects of matrine on lipopolysaccharide (LPS)-induced inflammation and oxidative stress in vivo and in vitro. The results showed that matrine improved intestinal inflammatory status and oxidative balance and enhanced chemokine receptor 7 (CCR7) expression. In LPS-challenged mice and Caco-2 cells, matrine alleviated LPS-induced inflammation and oxidative stress via downregulating pro-inflammatory cytokines (IL-1β and IL-17) and malondialdeh  ...[more]

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