Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal.
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ABSTRACT:
SUBMITTER: Wu G
PROVIDER: S-EPMC5355291 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal.
Wu Guojun G Zhou Wenhong W Zhao Junfeng J Pan Xiaohua X Sun Yongjie Y Xu Hao H Shi Peng P Geng Chong C Gao Ling L Tian Xingsong X
Oncotarget 20170201 7
The aim of this study was to investigate the protective effects of matrine on lipopolysaccharide (LPS)-induced inflammation and oxidative stress in vivo and in vitro. The results showed that matrine improved intestinal inflammatory status and oxidative balance and enhanced chemokine receptor 7 (CCR7) expression. In LPS-challenged mice and Caco-2 cells, matrine alleviated LPS-induced inflammation and oxidative stress via downregulating pro-inflammatory cytokines (IL-1β and IL-17) and malondialdeh ...[more]
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