Ontology highlight
ABSTRACT:
SUBMITTER: Deplus R
PROVIDER: S-EPMC5355307 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Deplus Rachel R Delliaux Carine C Marchand Nathalie N Flourens Anne A Vanpouille Nathalie N Leroy Xavier X de Launoit Yvan Y Duterque-Coquillaud Martine M
Oncotarget 20170201 7
Bone metastasis is the major deleterious event in prostate cancer (PCa). TMPRSS2-ERG fusion is one of the most common chromosomic rearrangements in PCa. However, its implication in bone metastasis development is still unclear. Since bone metastasis starts with the tropism of cancer cells to bone through specific migratory and invasive processes involving osteomimetic capabilities, it is crucial to better our understanding of the influence of TMPRSS2-ERG expression in the mechanisms underlying th ...[more]