Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway.
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ABSTRACT:
SUBMITTER: Wang XX
PROVIDER: S-EPMC5355310 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway.
Wang Xiao-Xiong XX Xiao Fu-Hui FH Li Qi-Gang QG Liu Jia J He Yong-Han YH Kong Qing-Peng QP
Oncotarget 20170201 7
Tumorigenesis is linked to the role of DNA methylation in gene expression regulation. Yet, cancer is a highly heterogeneous disease in which the global pattern of DNA methylation and gene expression, especially across diverse cancers, is not well understood. We investigated DNA methylation status and its association with gene expressions across 12 solid cancer types obtained from The Cancer Genome Atlas. Results showed that global hypermethylation was an important characteristic across all 12 ca ...[more]
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