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The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World.

ABSTRACT: West Nile virus (WNV) recently became a major public health concern in North America, the Middle East, and Europe. In contrast with the investigations of the North-American isolates, the neurovirulence properties of Middle-Eastern strains of WNV have not been extensively characterized. Israeli WNV strain IS-98-ST1 that has been isolated from a white stork in 1998, was found to be highly neuroinvasive in adult C57BL/6 mice. Strain IS-98-ST1 infects primary neuronal cells from mouse cortex, causing neuronal death. These results demonstrate that Israeli strain IS-98-ST1 provides a suitable viral model for WNV-induced disease associated with recent WNV outbreaks in the Old World.

SUBMITTER: Lucas M

PROVIDER: S-EPMC535539 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature

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The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World.

Lucas Marianne M Frenkiel Marie-Pascale MP Mashimo Tomoji T Guénet Jean-Louis JL Deubel Vincent V Desprès Philippe P Ceccaldi Pierre-Emmanuel PE

Virology journal 20041118

West Nile virus (WNV) recently became a major public health concern in North America, the Middle East, and Europe. In contrast with the investigations of the North-American isolates, the neurovirulence properties of Middle-Eastern strains of WNV have not been extensively characterized. Israeli WNV strain IS-98-ST1 that has been isolated from a white stork in 1998, was found to be highly neuroinvasive in adult C57BL/6 mice. Strain IS-98-ST1 infects primary neuronal cells from mouse cortex, causin ...[more]

PMID: 15550172

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