Effects of Polymer Length and Salt Concentration on the Transport of ssDNA in Nanofluidic Channels.

ABSTRACT: Electrokinetic phenomena in micro/nanofluidic channels have attracted considerable attention because precise control of molecular transport in liquids is required to optically and electrically capture the behavior of single molecules. However, the detailed mechanisms of polymer transport influenced by electroosmotic flows and electric fields in micro/nanofluidic channels have not yet been elucidated. In this study, a Langevin dynamics simulation was used to investigate the electrokinetic transport of single-stranded DNA (ssDNA) in a cylindrical nanochannel, employing a coarse-grained bead-spring model that quantitatively reproduced the radius of gyration, diffusion coefficient, and electrophoretic mobility of the polymer. Using this practical scale model, transport regimes of ssDNA with re

SUBMITTER: Qian W 

PROVIDER: S-EPMC5355498 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature