Ontology highlight
ABSTRACT:
SUBMITTER: Isaka Y
PROVIDER: S-EPMC5355535 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Isaka Yuta Y Ekimoto Toru T Kokabu Yuichi Y Yamato Ichiro I Murata Takeshi T Ikeguchi Mitsunori M
Biophysical journal 20170301 5
Enterococcus hirae V<sub>1</sub>-ATPase is a molecular motor composed of the A<sub>3</sub>B<sub>3</sub> hexamer ring and the central stalk. In association with ATP hydrolysis, three catalytic AB pairs in the A<sub>3</sub>B<sub>3</sub> ring undergo conformational changes, which lead to a 120° rotation of the central stalk. To understand how the conformational changes of three catalytic pairs induce the 120° rotation of the central stalk, we performed multiscale molecular dynamics (MD) simulations ...[more]