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Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy.

ABSTRACT: Mn-based nanoparticles have been regarded as a new class of probes for magnetic resonance imaging (MRI), but their low relaxivity is the major obstacle for applications in vivo. Herein, we designed and constructed a multifunctional nanotheranostic (FA-Mn₃O₄@PDA@PEG) for MRI guided combinatorial chemo-/photothermal therapy (PTT) for cancer. The ultrahigh relaxivity of 14.47 mM^-1 s^-1 makes the nanotheranostic an excellent contrast agent for MRI in vitro and in vivo, and provides comprehensive information for tumor diagnosis. When irradiated with an 808 nm NIR laser, FA-Mn₃O₄@PDA@PEG exhibits a remarkably improved and synergistic therapeutic effect compared to PTT or chemotherapy alone, providing high therapeutic efficiency and low side effects of drugs. These findings are of great interest and will inspire us to develop highly effective MRI guided synergetic chemo-/photothermal therapy for cancer treatment.

SUBMITTER: Ding X

PROVIDER: S-EPMC5355856 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy.

Ding Xing X Liu Jianhua J Li Junqi J Wang Fan F Wang Yinghui Y Song Shuyan S Zhang Hongjie H

Chemical science 20160706 11

Mn-based nanoparticles have been regarded as a new class of probes for magnetic resonance imaging (MRI), but their low relaxivity is the major obstacle for applications in vivo. Herein, we designed and constructed a multifunctional nanotheranostic (FA-Mn3O4@PDA@PEG) for MRI guided combinatorial chemo-/photothermal therapy (PTT) for cancer. The ultrahigh relaxivity of 14.47 mM-1 s-1 makes the nanotheranostic an excellent contrast agent for MRI <i ...[more]

PMID: 28451112

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Project description:Development of nanomedicines to overcome the hindrances of tumor microenvironment (TME) for tumor theranostics with alleviated side effects remains challenging. We report here a microfluidic synthesis of artesunate (ART)-loaded polydopamine (PDA)/iron (Fe) nanocomplexes (NCs) coated with fibronectin (FN). The created multifunctional Fe-PDA@ART/FN NCs (FDRF NCs) with a mean size of 161.0 nm exhibit desired colloidal stability, monodispersity, r1 relaxivity (4.96 mM−1s−1), and biocompatibility. The co-delivery of the Fe2+ and ART enables enhanced chemodynamic therapy (CDT) through improved intracellular reactive oxygen species generation via a cycling reaction between Fe3+ and Fe2+ caused by the Fe3+-mediated glutathione oxidation and Fe2+-mediated ART reduction/Fenton reaction for self-supplementing TME regulation. Likewise, the combination of ART-mediated chemotherapy and the Fe2+/ART-regulated enhanced CDT enables noticeable immunogenic cell death, which can be collaborated with antibody-mediated immune checkpoint blockade to exert immunotherapy having significant antitumor immunity. The combined therapy improves the efficacy of primary tumor therapy and tumor metastasis inhibition by virtue of FN-mediated specific targeting of FDRF NCs to tumors with highly expressed αvβ3 integrin and can be guided through the Fe(III)-rendered magnetic resonance (MR) imaging. The developed FDRF NCs may be regarded as an advanced nanomedicine formulation for chemo-chemodynamic-immune therapy of different tumor types under MR imaging guidance. Graphical abstract Image 1 Highlights • Intelligent Fe-PDA@ART/FN NCs can be prepared via microfluidics.• FDRF NCs have dual-pathway enhanced ROS generation ability.• Sustained TME regulation is achieved via a cycling reaction between Fe3+ and Fe2+.• Combined therapy-induced ICD can significantly activate antitumor immune response.• FDRF NCs enable MR imaging and ICB-integrated tri-mode tumor therapy.

Dataset Information

Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy.

Publications

Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy.

Similar Datasets

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