Ontology highlight
ABSTRACT:
SUBMITTER: Low CM
PROVIDER: S-EPMC5355877 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20170317
The pro-inflammatory mediator leukotriene B<sub>4</sub> (LTB<sub>4</sub>) is implicated in the pathologies of an array of diseases and thus represents an attractive therapeutic target. The enzyme leukotriene A<sub>4</sub> hydrolase (LTA<sub>4</sub>H) catalyses the distal step in LTB<sub>4</sub> synthesis and hence inhibitors of this enzyme have been actively pursued. Despite potent LTA<sub>4</sub>H inhibitors entering clinical trials all have failed to show efficacy. We recently identified a sec ...[more]