Ontology highlight
ABSTRACT:
SUBMITTER: Furlan D
PROVIDER: S-EPMC5355935 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Furlan Daniela D Trapani Davide D Berrino Enrico E Debernardi Carla C Panero Mara M Libera Laura L Sahnane Nora N Riva Cristina C Tibiletti Maria Grazia MG Sessa Fausto F Sapino Anna A Venesio Tiziana T
British journal of cancer 20170131 6
<h4>Background</h4>A compromised base excision repair (BER) promotes carcinogenesis by accumulating oxidative DNA-damaged products as observed in MUTYH-associated polyposis, a hereditary colorectal cancer syndrome marked by adenomas and cancers with an accumulation of 8-oxoguanine. Remarkably, DNA global demethylation has been shown to be mediated by BER, suggesting a relevant interplay with early colorectal tumourigenesis. To check this hypothesis, we investigated a cohort of 49 adenomas and 10 ...[more]