Structure-efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds.
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ABSTRACT:
SUBMITTER: Letort S
PROVIDER: S-EPMC5355938 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Structure-efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds.
Letort Sophie S Bosco Michaël M Cornelio Benedetta B Brégier Frédérique F Daulon Sébastien S Gouhier Géraldine G Estour François F
Beilstein journal of organic chemistry 20170306
New derivatives of cyclodextrins were prepared in order to determine the relative importance of the structural key elements involved in the degradation of organophosphorus nerve agents. To avoid a competitive inclusion between the organophosphorus substrate and the iodosobenzoate group, responsible for its degradation, the latter group had to be covalently bound to the cyclodextrin scaffold. Although the presence of the α nucleophile iodosobenzoate was a determinant in the hydrolysis process, an ...[more]
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