Integrated multi-ISE arrays with improved sensitivity, accuracy and precision.

ABSTRACT: Increasing use of ion-selective electrodes (ISEs) in the biological and environmental fields has generated demand for high-sensitivity ISEs. However, improving the sensitivities of ISEs remains a challenge because of the limit of the Nernstian slope (59.2/n mV). Here, we present a universal ion detection method using an electronic integrated multi-electrode system (EIMES) that bypasses the Nernstian slope limit of 59.2/n mV, thereby enabling substantial enhancement of the sensitivity of ISEs. The results reveal that the response slope is greatly increased from 57.2 to 1711.3 mV, 57.3 to 564.7 mV and 57.7 to 576.2 mV by electronic integrated 30 Cl^- electrodes, 10 F^- electrodes and 10 glass pH electrodes, respectively. Thus, a tiny change in the ion concentration can be

SUBMITTER: Wang C 

PROVIDER: S-EPMC5356001 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature