The Golgi protein ACBD3 facilitates Enterovirus 71 replication by interacting with 3A.
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ABSTRACT:
SUBMITTER: Lei X
PROVIDER: S-EPMC5356004 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
The Golgi protein ACBD3 facilitates Enterovirus 71 replication by interacting with 3A.
Lei Xiaobo X Xiao Xia X Zhang Zhenzhen Z Ma Yijie Y Qi Jianli J Wu Chao C Xiao Yan Y Zhou Zhuo Z He Bin B Wang Jianwei J
Scientific reports 20170317
Enterovirus 71 (EV71) is a human pathogen that causes hand, foot, mouth disease and neurological complications. Although EV71, as well as other enteroviruses, initiates a remodeling of intracellular membrane for genomic replication, the regulatory mechanism remains elusive. By screening human cDNA library, we uncover that the Golgi resident protein acyl-coenzyme A binding domain-containing 3 (ACBD3) serves as a target of the 3A protein of EV71. This interaction occurs in cells expressing 3A or i ...[more]
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