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Characterizing and prognosticating chronic lymphocytic leukemia in the elderly: prospective evaluation on 455 patients treated in the United States.


ABSTRACT: Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is?>?70 years. However, the majority of clinical trials do not reflect the demographics of CLL patients treated in the community. We examined treatment patterns, outcomes, and disease-related mortality in patients???75 years with CLL (E-CLL) in a real-world setting.The Connect® CLL registry is a multicenter, prospective observational cohort study, which enrolled 1494 adult patients between 2010-2014, at 199 US sites. Patients with CLL were enrolled within 2 months of initiating first line of therapy (LOT1) or a subsequent LOT (LOT???2). Kaplan-Meier methods were used to evaluate overall survival. CLL- and infection-related mortality were assessed using cumulative incidence functions (CIF) and cause-specific hazards. Logistic regression was used to develop a classification model.A total of 455 E-CLL patients were enrolled; 259 were enrolled in LOT1 and 196 in LOT???2. E-CLL patients were more likely to receive rituximab monotherapy (19.3 vs. 8.6%; p?

SUBMITTER: Nabhan C 

PROVIDER: S-EPMC5356242 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Characterizing and prognosticating chronic lymphocytic leukemia in the elderly: prospective evaluation on 455 patients treated in the United States.

Nabhan Chadi C   Mato Anthony A   Flowers Christopher R CR   Grinblatt David L DL   Lamanna Nicole N   Weiss Mark A MA   Davids Matthew S MS   Swern Arlene S AS   Bhushan Shriya S   Sullivan Kristen K   Flick E Dawn ED   Kiselev Pavel P   Sharman Jeff P JP  

BMC cancer 20170316 1


<h4>Background</h4>Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is > 70 years. However, the majority of clinical trials do not reflect the demographics of CLL patients treated in the community. We examined treatment patterns, outcomes, and disease-related mortality in patients ≥ 75 years with CLL (E-CLL) in a real-world setting.<h4>Methods</h4>The Connect® CLL registry is a multicenter, prospective observational cohort study, which enrolled 1494 adult patients betw  ...[more]

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