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Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial.


ABSTRACT: BACKGROUND:Sickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammation and multiple organ damage in sickle cell disease (SCD). Thus, antioxidant medication may favorably influence the disease. Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree, has been claimed to act as an anti-oxidant and cytoprotective agent, protecting against experimental hepatic, renal and cardiac toxicities in rats. We hypothesized that regular intake of GA increases anti-oxidant capacity and reduce oxidative stress. METHODS:Forty-seven patients (5-42 years) carrying hemoglobin SS were recruited. Patients received 30 g/day GA for 12 weeks. Total anti-oxidant capacity (TAC), malondialdehyde (MDA) and hydrogen peroxide (H2O2) levels were measured by spectrophotometric methods before and after GA intake. Complete blood count was measured by sysmex. RESULTS:Gum Arabic significantly increased TAC level P?

SUBMITTER: Kaddam L 

PROVIDER: S-EPMC5356407 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial.

Kaddam Lamis L   Fadl-Elmula Imad I   Eisawi Omer Ali OA   Abdelrazig Haydar Awad HA   Salih Mohammed Abdelraman MA   Lang Florian F   Saeed Amal M AM  

BMC hematology 20170316


<h4>Background</h4>Sickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammation and multiple organ damage in sickle cell disease (SCD). Thus, antioxidant medication may favorably influence the disease. Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree, has been claimed to act as an anti-oxidant and cytoprotective agent, protec  ...[more]

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