The Effect of Treatment Advances on the Mortality Results of Breast Cancer Screening Trials: A Microsimulation Model.

ABSTRACT:

Background

Mammography trials, which are the primary sources of evidence for screening benefit, were conducted decades ago. Whether advances in systemic therapies have rendered previously observed benefits of screening less significant is unknown.

Objective

To compare the outcomes of breast cancer screening trials had they been conducted using contemporary systemic treatments with outcomes of trials conducted with previously used treatments.

Design

Computer simulation model of 3 virtual screening trials with similar reductions in advanced-stage cancer cases but reflecting treatment patterns in 1975 (prechemotherapy era), 1999, or 2015 (treatment according to receptor status).

Data sources

Meta-analyses of screening and treatment trials; study of dissemination o

SUBMITTER: Birnbaum J 

PROVIDER: S-EPMC5356482 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature