Ontology highlight
ABSTRACT:
SUBMITTER: Qian H
PROVIDER: S-EPMC5356501 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Qian H H Qian H H Tay C Y CY Setyawati M I MI Chia S L SL Lee D S DS Leong D T DT
Chemical science 20160914 2
Tumor suppressive microRNAs are potent molecules that might cure cancer, one day. Despite the many advanced strategies for delivery of these microRNAs to the cell, there are few therapeutic microRNAs in clinical use. Progress in microRNA bioapplications is hindered by a high vulnerability of exogeneous microRNA molecules to RNase degradation that occurs in extra- and intracellular physiological conditions. In this proof-of-concept study, we use a programmable self-assembled DNA nanostructure bea ...[more]