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Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma.


ABSTRACT: Osteosarcoma (OS) is the most common primary bone malignancy with a poor prognosis for all races and both sexes. In this study, we found that miR-381 is a positive prognosis factor for OS patients that OS patients with a low expression of miR-381 had a longer survival time after surgical intervention, and miR-381 expression promotes MG-63 cell proliferation and cell invasion ability. Our results also showed a strong negative correlation between the expression of miR-381 and LRRC4 (brain relative specific expression gene) in OS tissues. This demonstrated that LRRC4 is a direct target gene of miR-381, and suppressing the expression of miR-381 increases the sensitivity of OS cells to chemotherapeutic drugs through the LRRC4-mediated mTOR pathway. In summary, miR-381 is an important biomarker in directing therapeutic intervention and predicting prognosis in OS patients.

SUBMITTER: Li Y 

PROVIDER: S-EPMC5356575 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma.

Li Yunchao Y   Zhao Chunhua C   Yu Zhibin Z   Chen Jiarui J   She Xiaoling X   Li Peiyao P   Liu Changhong C   Zhang Yan Y   Feng Jianbo J   Fu Haijuan H   Wang Bing B   Kuang Lei L   Li Lei L   Lv Guohua G   Wu Minghua M  

Oncotarget 20161001 42


Osteosarcoma (OS) is the most common primary bone malignancy with a poor prognosis for all races and both sexes. In this study, we found that miR-381 is a positive prognosis factor for OS patients that OS patients with a low expression of miR-381 had a longer survival time after surgical intervention, and miR-381 expression promotes MG-63 cell proliferation and cell invasion ability. Our results also showed a strong negative correlation between the expression of miR-381 and LRRC4 (brain relative  ...[more]

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