Ontology highlight
ABSTRACT:
SUBMITTER: Beer AG
PROVIDER: S-EPMC5356585 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Oncotarget 20161001 42
Low-density lipoprotein (LDL) receptor-related protein 1B (LRP1B), a member of the LDL receptor family, is frequently inactivated in multiple malignancies including lung cancer. LRP1B is therefore considered as a putative tumor suppressor. Due to its large size (4599 amino acids), until now only minireceptors or receptor fragments have been successfully cloned. To assess the effect of LRP1B on the proliferation of non-small cell lung cancer cells, we constructed and expressed a transfection vect ...[more]