Cyanidin-3-o-glucoside directly binds to ER?36 and inhibits EGFR-positive triple-negative breast cancer.
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ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC5356596 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancer.
Wang Li L Li Haifeng H Yang Shiping S Ma Wenqiang W Liu Mei M Guo Shichao S Zhan Jun J Zhang Hongquan H Tsang Suk Ying SY Zhang Ziding Z Wang Zhaoyi Z Li Xiru X Guo Yang-Dong YD Li Xiangdong X
Oncotarget 20161001 42
Anthocyanins have been shown to inhibit the growth and metastatic potential of breast cancer (BC) cells. However, the effects of individual anthocyanins on triple-negative breast cancer (TNBC) have not yet been studied. In this study, we found that cyanidin-3-o-glucoside (Cy-3-glu) preferentially promotes the apoptosis of TNBC cells, which co-express the estrogen receptor alpha 36 (ERα36) and the epidermal growth factor receptor (EGFR). We demonstrated that Cy-3-glu directly binds to the ligand- ...[more]
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