FOXC1 promotes melanoma by activating MST1R/PI3K/AKT.
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ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC5356666 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
FOXC1 promotes melanoma by activating MST1R/PI3K/AKT.
Wang Jinhua J Li Li L Liu Shiwei S Zhao Ying Y Wang Lin L Du Guanhua G
Oncotarget 20161201 51
FOXC1 is a member of Forkhead box family transcription factors. We showed that FOXC1 level was increased in melanoma cells and tissues and correlated with hypomethylation of the FOXC1 gene. Overexpression of FOXC1 promoted proliferation, migration, invasion, colony formation and growth in 3D Matrigel of melanoma cells. FOXC1 increased MST1R and activated the PI3K/AKT pathway. Also, FOXC1 expression was associated with disease progression and poor prognosis of melanoma. We suggest that FOXC1 is a ...[more]
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