Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Chu Q
PROVIDER: S-EPMC5356689 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma.
Chu Qun Q Jiang Yanan Y Zhang Wei W Xu Chaoqian C Du Weijie W Tuguzbaeva Gulnara G Qin Ying Y Li Anqi A Zhang Liangshuan L Sun Guiyuan G Cai Yongqiao Y Feng Qiang Q Li Guiyang G Li Yanyao Y Du Zhimin Z Bai Yunlong Y Yang Baofeng B
Oncotarget 20161201 51
Pyroptosis is a caspase-1 dependent programmed cell death, which is involved in the pathologic process of several kinds of cancers. Loss of caspase-1 gene expression has been observed in prostate and gastric cancers. However, the role of pyroptosis in human hepatocellular carcinoma (HCC) remains largely unknown. The aim of this study was to investigate the involvement of pyroptosis in the pathogenesis of HCC. Our study showed that pyroptosis was inhibited in HCC tissues and cells. Administration ...[more]
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