Ontology highlight
ABSTRACT:
SUBMITTER: Yang XF
PROVIDER: S-EPMC5356872 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Yang Xue-Feng XF Zhao Zhi-Juan ZJ Liu Jia-Jie JJ Yang Xiang-Hong XH Gao Yang Y Zhao Shuang S Shi Shuai S Huang Ke-Qiang KQ Zheng Hua-Chuan HC
Oncotarget 20170101 2
To elucidate the anti-tumor effects and molecular mechanisms of SAHA (a histone deacetylase inhibitor) and MG132 (a proteasome inhibitor) on the aggressive phenotypes of glioma cells, we treated U87 and U251 cells with SAHA or/and MG132, and detected phenotypes' assays with phenotype-related molecules examined. It was found that SAHA or/and MG132 treatment suppressed proliferation in both concentration- and time-dependent manners, inhibited energy metabolism, migration, invasion and lamellipodia ...[more]