Unknown

Dataset Information

0

Prospects for a Zika Virus Vaccine.


ABSTRACT: A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current state of ZIKV vaccine development. We discuss different vaccination strategies and we highlight challenges facing clinical evaluation of ZIKV vaccine candidates.

SUBMITTER: Barouch DH 

PROVIDER: S-EPMC5357134 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Prospects for a Zika Virus Vaccine.

Barouch Dan H DH   Thomas Stephen J SJ   Michael Nelson L NL  

Immunity 20170201 2


A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current sta  ...[more]

Similar Datasets

| S-EPMC5854011 | biostudies-literature
| S-EPMC7157504 | biostudies-literature
| S-EPMC3562718 | biostudies-literature
| S-EPMC6123396 | biostudies-literature
| S-EPMC6112613 | biostudies-literature
| S-EPMC8707647 | biostudies-literature
| S-EPMC7990201 | biostudies-literature
| S-EPMC5003703 | biostudies-literature
| S-EPMC5436897 | biostudies-literature
| S-EPMC6292895 | biostudies-other