Ontology highlight
ABSTRACT:
SUBMITTER: Cheng CW
PROVIDER: S-EPMC5357144 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Cheng Chia-Wei CW Villani Valentina V Buono Roberta R Wei Min M Kumar Sanjeev S Yilmaz Omer H OH Cohen Pinchas P Sneddon Julie B JB Perin Laura L Longo Valter D VD
Cell 20170201 5
Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the removal of impaired tissue and activation of a program leading to organ regeneration pose major challenges. In mice, a 4-day fasting mimicking diet (FMD) induces a stepwise expression of Sox17 and Pdx-1, followed by Ngn3-driven generation of insulin-producing β cells, resembling that observed during pancreatic development. FMD cycles restore insulin secretion and glucose homeostasis in both type 2 and type ...[more]