Two modes of enteric gliotransmission differentially affect gut physiology.
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ABSTRACT:
SUBMITTER: Grubisic V
PROVIDER: S-EPMC5357187 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Two modes of enteric gliotransmission differentially affect gut physiology.
Grubišić Vladimir V Parpura Vladimir V
Glia 20170207 5
Enteric glia (EG) in the enteric nervous system can modulate neuronally regulated gut functions. Using molecular genetics, we assessed the effects that molecular entities expressed in EG and otherwise mediating two distinct mechanisms of gliotransmitter release, connexin 43 (Cx43) hemichannel vs. Ca<sup>2+</sup> -dependent exocytosis, have on gut function. The expression of mutated Cx43<sup>G138R</sup> (which favors hemichannel, as opposed to gap-junctional activity) in EG increased gut motility ...[more]
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