Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment.
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ABSTRACT:
SUBMITTER: Koury J
PROVIDER: S-EPMC5357538 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment.
Koury Jeffrey J Zhong Li L Hao Jijun J
Stem cells international 20170305
The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. The CSCs are accountable for tumor initiation, growth, and recurre ...[more]
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