Dataset Information

High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study.

ABSTRACT:

Background

Recent studies have highlighted the clinical usefulness of near-infrared spectroscopy (NIRS) in psychiatry. However, the potential effects of psychotropics on NIRS signals remain unknown.

Methods

We conducted a systematic chart review of 40 depressed patients who underwent NIRS scans during a verbal fluency task to clarify the relationships between psychotropic dosage and NIRS signals. The dosage of psychotropic medications was calculated using defined daily dose (DDD). We investigated the associations between the DDD of psychotropic medications and oxygenated hemoglobin (oxy-Hb) in single channel levels.

Limitations

Retrospective study design and small sample size are the main limitations.

Results

Multiple regression analysis revealed that one channel in the right temporoparietal region had a significant association with antidepressant DDD controlling for age, sex, depression severity, and the DDD of antipsychotics and benzodiazepines. Moreover, high doses of antidepressants had significant effects on NIRS signals compared with low doses, in group comparisons.

Conclusions

The dose-dependent impact of antidepressants on NIRS signals should be taken into account when interpreting NIRS data.

SUBMITTER: Takamiya A

PROVIDER: S-EPMC5357702 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study.

Takamiya Akihiro A Hirano Jinichi J Ebuchi Yuki Y Ogino Satoyuki S Shimegi Kenichi K Emura Hiroyuki H Yonemori Kyoko K Shimazawa Akiko A Miura Gentaro G Hyodo Ayako A Hyodo Sari S Nagai Tunetaka T Funaki Madoka M Sugihara Masako M Kita Mitsuhiro M Yamagata Bun B Mimura Masaru M

NeuroImage. Clinical 20170213

<h4>Background</h4>Recent studies have highlighted the clinical usefulness of near-infrared spectroscopy (NIRS) in psychiatry. However, the potential effects of psychotropics on NIRS signals remain unknown.<h4>Methods</h4>We conducted a systematic chart review of 40 depressed patients who underwent NIRS scans during a verbal fluency task to clarify the relationships between psychotropic dosage and NIRS signals. The dosage of psychotropic medications was calculated using defined daily dose (DDD). ...[more]

PMID: 28348956

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Project description:BackgroundPatients undergoing surgical procedures are vulnerable to repetitive evoked or ongoing nociceptive barrage. Using functional near infrared spectroscopy, the authors aimed to evaluate the cortical hemodynamic signal power changes during ongoing nociception in healthy awake volunteers and in surgical patients under general anesthesia. The authors hypothesized that ongoing nociception to heat or surgical trauma would induce reductions in the power of cortical low-frequency hemodynamic oscillations in a similar manner as previously reported using functional magnetic resonance imaging for ongoing pain.MethodsCortical hemodynamic signals during noxious stimuli from the fontopolar cortex were evaluated in two groups: group 1, a healthy/conscious group (n = 15, all males) where ongoing noxious and innocuous heat stimulus was induced by a contact thermode to the dorsum of left hand; and group 2, a patient/unconscious group (n = 13, 3 males) receiving general anesthesia undergoing knee surgery. The fractional power of low-frequency hemodynamic signals was compared across stimulation conditions in the healthy awake group, and between patients who received standard anesthesia and those who received standard anesthesia with additional regional nerve block.ResultsA reduction of the total fractional power in both groups-specifically, a decrease in the slow-5 frequency band (0.01 to 0.027 Hz) of oxygenated hemoglobin concentration changes over the frontopolar cortex-was observed during ongoing noxious stimuli in the healthy awake group (paired t test, P = 0.017; effect size, 0.70), and during invasive procedures in the surgery group (paired t test, P = 0.003; effect size, 2.16). The reduction was partially reversed in patients who received a regional nerve block that likely diminished afferent nociceptive activity (two-sample t test, P = 0.002; effect size, 2.34).ConclusionsThese results suggest common power changes in slow-wave cortical hemodynamic oscillations during ongoing nociceptive processing in conscious and unconscious states. The observed signal may potentially promote future development of a surrogate signal to assess ongoing nociception under general anesthesia.Editor’s perspective

Dataset Information

High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study.

Background

Methods

Limitations

Results

Conclusions

Publications

High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study.

Similar Datasets

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