Membrane remodeling by the M2 amphipathic helix drives influenza virus membrane scission.
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ABSTRACT:
SUBMITTER: Martyna A
PROVIDER: S-EPMC5357790 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Membrane remodeling by the M2 amphipathic helix drives influenza virus membrane scission.
Martyna Agnieszka A Bahsoun Basma B Badham Matthew D MD Srinivasan Saipraveen S Howard Mark J MJ Rossman Jeremy S JS
Scientific reports 20170320
Membrane scission is a crucial step in all budding processes, from endocytosis to viral budding. Many proteins have been associated with scission, though the underlying molecular details of how scission is accomplished often remain unknown. Here, we investigate the process of M2-mediated membrane scission during the budding of influenza viruses. Residues 50-61 of the viral M2 protein bind membrane and form an amphipathic α-helix (AH). Membrane binding requires hydrophobic interactions with the l ...[more]
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