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Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background.


ABSTRACT: The data herein is related to the research article entitled "Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis" (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (?IL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c Lcn2KO mice and their WT littermates to the ?IL-10R neutralization-induced chronic colitis. Our data showed that ?IL-10R mAb-treated BALB/c Lcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice.

SUBMITTER: Singh V 

PROVIDER: S-EPMC5358532 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background.

Singh Vishal V   Yeoh Beng San BS   Nilsen-Hamilton Marit M   Berger Thorsten T   Mak Tak W TW   Vijay-Kumar Matam M  

Data in brief 20170308


The data herein is related to the research article entitled "Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis" (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (<i>Lcn2</i>KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c <i>Lcn2</i>KO mice and their WT littermates  ...[more]

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