Ontology highlight
ABSTRACT:
SUBMITTER: Leung JW
PROVIDER: S-EPMC5358723 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Leung Justin W C JW Makharashvili Nodar N Agarwal Poonam P Chiu Li-Ya LY Pourpre Renaud R Cammarata Michael B MB Cannon Joe R JR Sherker Alana A Durocher Daniel D Brodbelt Jennifer S JS Paull Tanya T TT Miller Kyle M KM
Genes & development 20170227 3
Chromatin connects DNA damage response factors to sites of damaged DNA to promote the signaling and repair of DNA lesions. The histone H2A variants H2AX, H2AZ, and macroH2A represent key chromatin constituents that facilitate DNA repair. Through proteomic screening of these variants, we identified ZMYM3 (zinc finger, myeloproliferative, and mental retardation-type 3) as a chromatin-interacting protein that promotes DNA repair by homologous recombination (HR). ZMYM3 is recruited to DNA double-str ...[more]