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A significant productive in vivo infection of resting cells with simian immunodeficiency virus in a macaque with AIDS.

ABSTRACT: Identifying the cells that can be infected with HIV in vivo and thus potentially persist as latent reservoirs is of high priority. Here, we report the major infected cells in a chronically simian immunodeficiency virus (SIV)-infected macaque that developed AIDS and encephalitis. A majority of the infected cells were detected as non-proliferating resting cells. SIV-infected non-proliferating resting cells were found to be playing an important role in viral pathogenesis, persistence, or reservoir formation.

SUBMITTER: Pahar B 

PROVIDER: S-EPMC5359019 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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A significant productive in vivo infection of resting cells with simian immunodeficiency virus in a macaque with AIDS.

Pahar Bapi B   Lala Wendy W   Kuebler Dot D   Liu David D  

Journal of medical primatology 20170201 2

Identifying the cells that can be infected with HIV in vivo and thus potentially persist as latent reservoirs is of high priority. Here, we report the major infected cells in a chronically simian immunodeficiency virus (SIV)-infected macaque that developed AIDS and encephalitis. A majority of the infected cells were detected as non-proliferating resting cells. SIV-infected non-proliferating resting cells were found to be playing an important role in viral pathogenesis, persistence, or reservoir  ...[more]