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Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy.

ABSTRACT: Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity experienced in 30-40% of patients undergoing treatment with various chemotherapeutics, including taxanes, vinca alkaloids, epothilones, proteasome inhibitors, and thalidomide. Importantly, CIPN significantly affects a patient's quality of life. Recent genetic association studies are enhancing our understanding of CIPN pathophysiology and serve as a foundation for identification of genetic biomarkers to predict toxicity risk and for the development of novel strategies for prevention and treatment.

SUBMITTER: Chua KC

PROVIDER: S-EPMC5359049 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy.

Chua K C KC Kroetz D L DL

Clinical pharmacology and therapeutics 20170222 4

Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity experienced in 30-40% of patients undergoing treatment with various chemotherapeutics, including taxanes, vinca alkaloids, epothilones, proteasome inhibitors, and thalidomide. Importantly, CIPN significantly affects a patient's quality of life. Recent genetic association studies are enhancing our understanding of CIPN pathophysiology and serve as a foundation for identification of genetic biomarkers to predict t ...[more]

PMID: 27981569

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