Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury.
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ABSTRACT:
SUBMITTER: Tang Y
PROVIDER: S-EPMC5359186 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury.
Protein & cell 20170211 4
Tissue damage induces cells into reprogramming-like cellular state, which contributes to tissue regeneration. However, whether factors promoting the cell reprogramming favor tissue regeneration remains elusive. Here we identified combination of small chemical compounds including drug cocktails robustly promoting in vitro cell reprogramming. We then administrated the drug cocktails to mice with acute liver injuries induced by partial hepatectomy or toxic treatment. Our results demonstrated that t ...[more]
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