Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro.
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ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC5359216 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins <i>in vitro</i>.
Wu Yaoxing Y Liu Qingxiang Q Zhou Jie J Xie Weihong W Chen Cheng C Wang Zefang Z Yang Haitao H Cui Jun J
Cell discovery 20170321
Type I interferon (IFN) serves as the first line of defense against invading pathogens. Inhibition of IFN-triggered signaling cascade by Zika virus (ZIKV) plays a critical role for ZIKV to evade antiviral responses from host cells. Here we demonstrate that ZIKV nonstructural proteins NS1, NS4B and NS2B3 inhibit the induction of IFN and downstream IFN-stimulated genes through diverse strategies. NS1 and NS4B of ZIKV inhibit IFNβ signaling at TANK-binding kinase 1 level, whereas NS2B-NS3 of ZIKV i ...[more]
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