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Lesch-Nyhan syndrome: The saga of metabolic abnormalities and self-injurious behavior.


ABSTRACT: Lesch-Nyhan syndrome (LNS) is an X-linked recessive disorder of purine metabolism caused by a mutation in Xq26.2-q26.3 (OMIM 308000.0004). The presence of the diagnostic triad, i.e. signs of self-injurious behavior (SIB) and results of pedigree analysis and novel molecular biology & genetic testing, confirms the diagnosis of LNS. With a level of hypoxanthine guanine phosphoribosyl-transferase 1 (HPRT1) enzyme activity < 2%, patients develop neurological, neurocognitive, and neuromotor symptoms along with SIB. Described here is a case of 4-year-old boy who was diagnosed with LNS. The boy displayed SIB, i.e. biting of the lips and fingers, and he had cerebral venous sinus thrombosis caused by LNS.

SUBMITTER: Tewari N 

PROVIDER: S-EPMC5359358 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Lesch-Nyhan syndrome: The saga of metabolic abnormalities and self-injurious behavior.

Tewari Nitesh N   Mathur Vijay Prakash VP   Sardana Divesh D   Bansal Kalpana K  

Intractable & rare diseases research 20170201 1


Lesch-Nyhan syndrome (LNS) is an X-linked recessive disorder of purine metabolism caused by a mutation in Xq26.2-q26.3 (OMIM 308000.0004). The presence of the diagnostic triad, <i>i.e.</i> signs of self-injurious behavior (SIB) and results of pedigree analysis and novel molecular biology & genetic testing, confirms the diagnosis of LNS. With a level of hypoxanthine guanine phosphoribosyl-transferase 1 (HPRT1) enzyme activity < 2%, patients develop neurological, neurocognitive, and neuromotor sym  ...[more]

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