Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC5359587 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Yang Jihyun J Shim Sang-Mu SM Nguyen Thi Quyen TQ Kim Eun-Ha EH Kim Kwang K Lim Yong Taik YT Sung Moon-Hee MH Webby Richard R Poo Haryoung H
Scientific reports 20170321
In 2009, the global outbreak of an influenza pandemic emphasized the need for an effective vaccine adjuvant. In this study, we examined the efficacy of poly-γ-glutamic acid/chitosan (PC) nanogel as an adjuvant for the influenza vaccine. PC nanogel significantly enhanced antigen-specific cross-presentation and cytotoxic T lymphocyte (CTL) activity. Compared with alum, the protective efficacy of the pandemic H1N1 influenza (pH1N1) vaccine was substantially increased by PC nanogel, with increased h ...[more]