Ontology highlight
ABSTRACT:
SUBMITTER: Segura-Cabrera A
PROVIDER: S-EPMC5359624 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Segura-Cabrera Aldo A Tripathi Reshmi R Zhang Xiaoyi X Gui Lin L Chou Tsui-Fen TF Komurov Kakajan K
Scientific reports 20170321
Valosin-containing protein (VCP/p97) ATPase (a.k.a. Cdc48) is a key member of the ER-associated protein degradation (ERAD) pathway. ERAD and VCP/p97 have been implicated in a multitude of human diseases, such as neurodegenerative diseases and cancer. Inhibition of VCP/p97 induces proteotoxic ER stress and cell death in cancer cells, making it an attractive target for cancer treatment. However, no drugs exist against this protein in the market. Repositioning of drugs towards new indications is an ...[more]