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IsoSel: Protein Isoform Selector for phylogenetic reconstructions.

ABSTRACT: The reliability of molecular phylogenies is strongly dependent on the quality of the assembled datasets. In the case of eukaryotes, the selection of only one protein isoform per genomic locus is mandatory to avoid biases linked to redundancy. Here, we present IsoSel, a tool devoted to the selection of alternative isoforms in the context of phylogenetic reconstruction. It provides a better alternative to the widely used approach consisting in the selection of the longest isoforms and it performs better than Guidance, its only available counterpart. IsoSel is publicly available at http://doua.prabi.fr/software/isosel.

SUBMITTER: Philippon H

PROVIDER: S-EPMC5360266 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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IsoSel: Protein Isoform Selector for phylogenetic reconstructions.

Philippon Héloïse H Souvane Alexia A Brochier-Armanet Céline C Perrière Guy G

PloS one 20170321 3

The reliability of molecular phylogenies is strongly dependent on the quality of the assembled datasets. In the case of eukaryotes, the selection of only one protein isoform per genomic locus is mandatory to avoid biases linked to redundancy. Here, we present IsoSel, a tool devoted to the selection of alternative isoforms in the context of phylogenetic reconstruction. It provides a better alternative to the widely used approach consisting in the selection of the longest isoforms and it performs ...[more]

PMID: 28323858

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