Ontology highlight
ABSTRACT:
SUBMITTER: Matias S
PROVIDER: S-EPMC5360447 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Matias Sara S Lottem Eran E Dugué Guillaume P GP Mainen Zachary F ZF
eLife 20170321
Serotonin is implicated in mood and affective disorders. However, growing evidence suggests that a core endogenous role is to promote flexible adaptation to changes in the causal structure of the environment, through behavioral inhibition and enhanced plasticity. We used long-term photometric recordings in mice to study a population of dorsal raphe serotonin neurons, whose activity we could link to normal reversal learning using pharmacogenetics. We found that these neurons are activated by both ...[more]