Ontology highlight
ABSTRACT:
SUBMITTER: Anderson KL
PROVIDER: S-EPMC5360490 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Anderson Karen L KL Page Christopher C Swift Mark F MF Suraneni Praveen P Janssen Mandy E W MEW Pollard Thomas D TD Li Rong R Volkmann Niels N Hanein Dorit D
Journal of structural biology 20161221 3
Arp2/3 complex is thought to be the primary protrusive force generator in cell migration by controlling the assembly and turnover of the branched filament network that pushes the leading edge of moving cells forward. However, mouse fibroblasts without functional Arp2/3 complex migrate at rates similar to wild-type cells, contradicting this paradigm. We show by correlative fluorescence and large-scale cryo-tomography studies combined with automated actin-network analysis that the absence of funct ...[more]