Ontology highlight
ABSTRACT:
SUBMITTER: Hwang IY
PROVIDER: S-EPMC5360501 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Hwang Il-Young IY Park Chung C Harrison Kathleen K Kehrl John H JH
Journal of immunology (Baltimore, Md. : 1950) 20170224 7
Adaptive immunity depends on mature thymocytes leaving the thymus to enter the bloodstream and the trafficking of T cells through lymphoid organs. Both of these require heterotrimeric Gα<sub>i</sub> protein signaling, whose intensity and duration are controlled by the regulator of G protein signaling (RGS) proteins. In this study, we show that RGS protein/Gα<sub>i2</sub> interactions are essential for normal thymocyte egress, T cell trafficking, and homeostasis. Mature thymocytes with a Gα<sub>i ...[more]