Unknown

Dataset Information

0

Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways.


ABSTRACT: Akirin2, a novel nuclear factor, plays an important role in myogenesis. To investigate the role of Akirin2 in proliferation and differentiation of porcine skeletal muscle satellite cells, Akirin2 overexpression and Akirin2 silence technologies were employed. Our results showed that overexpression of Akirin2 markedly enhanced the proliferation and differentiation of porcine skeletal muscle satellite cells, whereas silencing of Akirin2 got the opposite results. Furthermore, our results showed that Akirin2 affected proliferation and differentiation of porcine skeletal muscle satellite cells through extracellular-signal regulated kinase-1/2 (ERK1/2) and NFATc1 signaling pathways. These results indicate that Akirin2 can effectively promote skeletal muscle satellite cells proliferation and differentiation, acting through ERK1/2- and NFATc1-dependent mechanisms.

SUBMITTER: Chen X 

PROVIDER: S-EPMC5361102 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways.

Chen Xiaoling X   Luo Yanliu Y   Huang Zhiqing Z   Jia Gang G   Liu Guangmang G   Zhao Hua H  

Scientific reports 20170322


Akirin2, a novel nuclear factor, plays an important role in myogenesis. To investigate the role of Akirin2 in proliferation and differentiation of porcine skeletal muscle satellite cells, Akirin2 overexpression and Akirin2 silence technologies were employed. Our results showed that overexpression of Akirin2 markedly enhanced the proliferation and differentiation of porcine skeletal muscle satellite cells, whereas silencing of Akirin2 got the opposite results. Furthermore, our results showed that  ...[more]

Similar Datasets

| S-EPMC8968951 | biostudies-literature
| S-EPMC7867548 | biostudies-literature
| S-EPMC8065989 | biostudies-literature
| S-EPMC3223495 | biostudies-literature
| S-EPMC4848725 | biostudies-literature
| S-EPMC4346940 | biostudies-literature
| S-EPMC8388737 | biostudies-literature
| S-EPMC11354305 | biostudies-literature
| S-EPMC7677141 | biostudies-literature
| S-EPMC10423287 | biostudies-literature