Ontology highlight
ABSTRACT:
SUBMITTER: Lees JA
PROVIDER: S-EPMC5361624 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Lees John A JA Kremer Philip H C PHC Manso Ana S AS Croucher Nicholas J NJ Ferwerda Bart B Serón Mercedes Valls MV Oggioni Marco R MR Parkhill Julian J Brouwer Matthijs C MC van der Ende Arie A van de Beek Diederik D Bentley Stephen D SD
Microbial genomics 20170131 1
Recent studies have provided evidence for rapid pathogen genome diversification, some of which could potentially affect the course of disease. We have previously described such variation seen between isolates infecting the blood and cerebrospinal fluid (CSF) of a single patient during a case of bacterial meningitis. Here, we performed whole-genome sequencing of paired isolates from the blood and CSF of 869 meningitis patients to determine whether such variation frequently occurs between these tw ...[more]