Resveratrol fuels HER2 and ER?-positive breast cancer behaving as proteasome inhibitor.
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ABSTRACT:
SUBMITTER: Andreani C
PROVIDER: S-EPMC5361678 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Resveratrol fuels HER2 and ERα-positive breast cancer behaving as proteasome inhibitor.
Andreani Cristina C Bartolacci Caterina C Wijnant Kathleen K Crinelli Rita R Bianchi Marzia M Magnani Mauro M Hysi Albana A Iezzi Manuela M Amici Augusto A Marchini Cristina C
Aging 20170201 2
The phytoestrogen resveratrol has been reported to possess cancer chemo-preventive activity on the basis of its effects on tumor cell lines and xenograft or carcinogen-inducible <i>in vivo</i> models. Here we investigated the effects of resveratrol on spontaneous mammary carcinogenesis using Δ16HER2 mice as HER2+/ERα+ breast cancer model. Instead of inhibiting tumor growth, resveratrol treatment (0.0001% in drinking water; daily intake of 4μg/mouse) shortened tumor latency and enhanced tumor mul ...[more]
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