Ontology highlight
ABSTRACT:
SUBMITTER: Gorshkov K
PROVIDER: S-EPMC5362298 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Gorshkov Kirill K Mehta Sohum S Ramamurthy Santosh S Ronnett Gabriele V GV Zhou Feng-Quan FQ Zhang Jin J
Nature chemical biology 20170213 4
Cyclic AMP (cAMP) and protein kinase A (PKA), classical examples of spatially compartmentalized signaling molecules, are critical axon determinants that regulate neuronal polarity and axon formation, yet little is known about micro-compartmentalization of cAMP and PKA signaling and its role in developing neurons. Here, we revealed that cAMP forms a gradient in developing hippocampal neurons, with higher cAMP levels in more distal regions of the axon compared to other regions of the cell. Interes ...[more]