Structure and specificity of a permissive bacterial C-prenyltransferase.
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ABSTRACT:
SUBMITTER: Elshahawi SI
PROVIDER: S-EPMC5362326 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Structure and specificity of a permissive bacterial C-prenyltransferase.
Elshahawi Sherif I SI Cao Hongnan H Shaaban Khaled A KA Ponomareva Larissa V LV Subramanian Thangaiah T Farman Mark L ML Spielmann H Peter HP Phillips George N GN Thorson Jon S JS Singh Shanteri S
Nature chemical biology 20170206 4
This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug. ...[more]
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