Within vs. between-subject effects of intranasal oxytocin on the neural response to cooperative and non-cooperative social interactions.

ABSTRACT: The neuropeptide oxytocin (OT) plays a critical role in modulating social behavior across a wide range of vertebrate species. In humans, intranasal oxytocin (INOT) has been shown to modulate various aspects of social behavior, such as empathy, trust, in-group preference, and memory of socially relevant cues. Most INOT studies employ cross-sectional designs despite the enhanced statistical power and reduction in error variance associated with individual differences characteristic of within-subject designs. Using the Prisoner Dilemma task, which models a real-life dyadic social interaction, our group has systematically explored the effect of INOT on social cooperation and non-cooperation using a cross-sectional design. In the current study, we investigated if the main findings from our cross

SUBMITTER: Chen X 

PROVIDER: S-EPMC5362337 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature