Valproic acid inhibits glioblastoma multiforme cell growth via paraoxonase 2 expression.
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ABSTRACT:
SUBMITTER: Tseng JH
PROVIDER: S-EPMC5362434 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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Valproic acid inhibits glioblastoma multiforme cell growth via paraoxonase 2 expression.
Tseng Jen-Ho JH Chen Cheng-Yi CY Chen Pei-Chun PC Hsiao Sheng-Huang SH Fan Chi-Chen CC Liang Yu-Chih YC Chen Chie-Pein CP
Oncotarget 20170201 9
We studied the potential mechanisms of valproic acid (VPA) in the treatment of glioblastoma multiforme (GBM). Using the human U87, GBM8401, and DBTRG-05MG GBM-derived cell lines, VPA at concentrations of 5 to 20 mM induced G2/M cell cycle arrest and increased the production of reactive oxygen species (ROS). Stress-related molecules such as paraoxonase 2 (PON2), cyclin B1, cdc2, and Bcl-xL were downregulated, but p27, p21 and Bim were upregulated by VPA treatment. VPA response element on the PON2 ...[more]
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